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BACKGROUND: Basic fibroblast growth factor (BFGF) widely in human tissue participates in trauma repair of various tissues and is one of wound healing factors in the body. OBJECTIVE: To summarize the progress of BFGF in the fracture healing. RETRIEVAL STRATEGY: A computer-based online search of Pubmed Database was undertaken to identify the relevant articles on BFGF in the fracture healing published from January 2000 to December 2007 with the Keywords of "fibroblast growth factor 2 (basic fibroblast growth factor), fracture healing, regulation, signal transduction" in English. At the same time, Chinese relevant articles were searched in China Journal Full-text Database (CJFD) and Wanfang Database published between January 2000 and December 2007 with the same key words in Chinese. Exclusive criteria included articles with repetitive research and non-original study. LITERATURE EVALUATION: A total of 33 articles were collected about the distribution (3 articles), biological characteristics (3 articles) and the effect on the healing of bone fracture (27 articles) of BFGF. DATA SYNTHESIS: Bone healing is the process of regeneration after bone injury and the process of bone formation. BFGF can promote the cell migration by its chemotaxis and accelerate the healing by aggregating mesenchymal stem cells, macrophage and fibroblasts towards trauma region. Present animal studies on BFGF are deep and reports on clinical application are a few. Thus, the effect of BFGF is available. BGFG can affect bone formation by adjusting cell prolifeation and differentiation and changing the synthesis of cell products. BGFG not only can promote the bone growth, but also enhance the adhesion of osteoblasts and scaffold. CONCLUSION: The distribution and biological characteristics of BGFG have been recognized primarily. The further study on modulatory mechanism in the fracture healing of BFGF is carrying through. The bone restoration compounded by BFGF and its carriers is in the experiment and needs to be studied further.
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Objective:This study was designed to measure the angles of the acetabular abduction when facing the different pelvic obliqueness angles.Methods:The angle of the acetabular abduction of 21 pelvis all 42 hip joints were measured with the manual devices when facing the 9 different pelvic obliqueness angles.Results:The pelvic obliqueness angle and abduction angle showed the positive linear correlation by the linear regress analysis.(r=0.999,P=0.000).The average abduction angle was 46.5?(43.8?-49.2?)when the obliqueness angle was 0?,as obliqueness angle of the pelvis increase to 10?,the abduction increase to 9.4?. Conclusion: The results provided reliable anatomical basis for total hip arthroplasty.
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The success of total hip replacement relies on detailed preoperative pla nning and reliable localization during operation.Currently,great advances have been made in the research and application of localization s ystem.The traditional preoperative planning is based on plain radiographs of the p elvis and femur as well as the profile outline of each prosthetic component.Now image-gu ided system(IGS)is used to perform virtual implantation.Surgeons used to localize during total hip replacement only wi th eyes or unreliable localization d evices,but now they begin to use imag e-guided system for surgical navigation during operation.[
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Objective: To explore the anatomy of tibiofibular syndesmosis for the clinic treatment of tib-iofibular syndesmosis injury. Methods: Twelve embalmed adult lower legs were selected. The configurations , structures and plane which ligaments attached to were observed. Results:Tibiofibular syndesmosis consists of ligaments, plica and synostosis. It's tower-shaped. The plane which ligaments attached to has a shape of swallow's tail. Conclusion:Tibiofibular syndesmosis is strong and elastic. The fixation of injuried tibiofibular syndesmosis should be elastic.
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0.05） . Strains of cemented groups were usually less than that of non-cemented ones for all zones except the stem tip zone. Normal group and osteoporosis group had different stress shielding and concentration(P
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OBJECTIVE: To study the clinical influence of fe moral quality on cementless hip replacement and to evaluate cortical index (CI) for femoral quality in order to guide prosthesis choice and rehabilitation. METHODS: Forty-nine cases of cementless hip replacement were followed up for average 3.5 years, 42 of whom had X-ray films on preopera tion or operation day. RESULTS: Harris scores and patients' satisfaction were low bu t pain was significant and prolonged when cortical indices were low. CONCLUSIONS: CI is a reliable semi-quantity parameter for clin ical evaluation of femoral quality. Osteoporosis patients predispose to thigh pa in. Lag for full-weight loading and avoidance for torsion motion can contribute to less pain when CI<=2.2.
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Objective To study the role of first metatarsal sesamoids s y stem in the pathogenesis of hallux valgus. Methods The sesamoids absolute and relative position (TSP) were measured in 245 normal feet and 141 hallux valgus ones, and the results were statistically analysed with hallux valgus angle(HVA), intermetatarsal angle(IMA) and metatarsal phalangeal joint subluxation. Results The absolute position of sesamoids had no difference in the normal feet and ha llux valgus ones. TSP was correlated with HVA,IMA. TSP≤3 was considered normal in 245 normal feet. 92 hallux valgus feet were surgically treated. 20 cases unde rgone Keller procedures which didnt correct TSP were excluded from this study. 19 cases treated with modified McBride procedures, 24 cases with metatarsal met aphyseal osteotomy, 29 cases with metatarsal basal osteotomy. All the cases were followed up for an average of 4 years(ranged 1－6 years). The postoperative HV A was 5?－10?(average 7?)，IMA was 5?－9?(average 7?)，TSP were all 3 or 4 . According to the evaluation standard made by SUN Junying et al, 60 cases(83％) were assessed as excellent， 8 cases(11％) as good， and 4 cases(6％) as worse ， giving an overall excellent and good rate of 94％. Conclusion TSP is an impo rtant parameter that should be routinely used for postoperative prognosis evalua tion and surgical procedures determination. Osteotomy is preferred to restore no rmal metatarsal-sesamoids system function when TSP is abnormal.